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Laboratory for Neurophysiology and Neuroimaging

Research interests

Within the Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, structural and functional MRI techniques (high resolution 3D imaging, MR volumetry, fMRI, functional connectivity, DTI) are combined with neurophysiological methods (MEG, EEG, event-related  potentials (ERP), synchronous oscillatory activity, fMRI constrained ERP source analysis), sophisticated neuropsychological assessments and neurogenetic and neurochemical methods in order to study the relationships between genetics, morphology and function of the brain in participants demonstrating cognitive decline. The main areas of clinical research of the Laboratory of Neuroscience include the investigation of dementia, schizophrenia, affective disorders and their precursors.

In close collaboration with the Brain Imaging Center, the Dept. of Neuroradiology, and a number of other institutes, our main research interest is focused on multimodal investigation of neuronal coordination as a basis for cognitive impairment and psychopathological symptoms.

This approach takes advantage of the integration of multiple scientific methods (neurogenetics, neurochemistry, neuroimaging, etc.) being applied to multiple patient groups (e.g. subjects with preclinical Alzheimer’s disease, MS patients, schizophrenia and bipolar affective patients). Close collaboration with physicists and mathematicians ensures that always the newest and most advanced analytical methods and statistical procedures are available to be applied to the generated data.

A perfect integration with our memory clinic, which has an astonishing throughput of dementia outpatients and subjects with subjective memory complaints, ensures that the needs of a high number of scientific projects can be easily met.

Our advanced organisational clinical concepts (e.g. the track-concept) also greatly help to keep in touch with subjects and patients over long periods of time, providing the opportunity for unique longitudinal projects.

Moreover, multiple collaborations with international partners and participation in multinational projects and networks makes sure that our lab is always at the forefront of scientific research.

We have also started to investigate whether processes of cognitive decline over time can be positively modulated by cognitive and by physical training and how far mechanisms of neural plasticity are preserved in preclinical Alzheimer`s Disease (AD), mild cognitive impairment (MCI) as well as in other psychiatric disorders such as affective disorders and schizophrenia.

In summary, our lab is based on a high integration of advanced interdisciplinary neuroscientific methods and it benefits greatly from its tight integration within the structures of the clinical department as well as from its successful and widespread international collaborations with leaders academic and industry partners worldwide.

 

geändert am 19. Februar 2013  E-Mail: Kontaktpsychiatrie@kgu.de

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Druckversion: 19. Februar 2013, 11:24
http://www.uni-frankfurt.de/fb/fb16/fachklinik/psychiatrie/Forschung/neurophysio/index.html